Overview
Sermorelin is a 29-amino acid analog of growth hormone releasing hormone. It works upstream of the pituitary to stimulate the animal's own growth hormone release. Physiologic pulses. Preserved feedback control. No supraphysiologic peaks.
Think of it as the senior dog vitality peptide.
Mechanism of action
- 01Binds the GHRH receptor on somatotroph cells in the anterior pituitary.
- 02Triggers endogenous pulsatile growth hormone release.
- 03Preserves negative feedback via IGF-1 and somatostatin.
- 04Restores age-related decline in GH pulse amplitude.
- 05Downstream IGF-1 supports muscle mass, coat quality, and cellular repair.
Molecular data
Species
Dog
Age-related GH decline mirrors human physiology. Muscle wasting in senior dogs. Recovery adjunct after major surgery. Cognitive dysfunction syndrome supportive care. Sermorelin is dog-only on the current nudaPETides prescription list. Feline endocrine biology differs and safety data is thinner.
Prescribing indications
- EndocrineSupportedSenior dogs with muscle wasting and sarcopenia.
- RecoverySupportedPost-surgical recovery in older patients.
- NeurologicEmergingCognitive dysfunction syndrome adjunct.
Dosing and administration
Starting, maintenance, and loading doses are calculated in the platform for the patient’s weight band, at the vial strength our compounding partner dispenses, and drawn to U-100 syringe units for the client’s dosing card. Any override is logged with your initials.
See the worked dose exampleScreening and safety
Screen first
Diabetes, hyperadrenocorticism, neoplasia. Not for cats
Follow up
WSAVA body and muscle condition scores. Watch glucose. Measure at baseline and recheck at 4 to 6 weeks with the same measure.
Endogenous pulsatile release preserves feedback control. Contraindicated in active malignancy given uncertain effects on tumor GH signaling.
Common pairings
- Sermorelin + CJC-1295 / IpamorelinCompatibleSequential dosing recommended.
References
Related
This monograph describes a compounded veterinary medication available by prescription only through a licensed veterinarian inside an active veterinarian-client-patient relationship. Not FDA-approved for animal or human use. Compounded on a patient-specific basis under FDA Guidance for Industry #256. For educational use by licensed veterinarians. Not intended for consumer self-prescribing.