Overview
Two peptides working in sequence. Ipamorelin is a selective ghrelin-mimetic that binds the GHSR-1a receptor. CJC-1295 without DAC extends GHRH signal duration. Together they deliver clean, pulsatile, physiological growth hormone release.
No cortisol bump. No prolactin elevation. That is the difference from older growth hormone secretagogues.
Mechanism of action
- 01Ipamorelin binds the GHSR-1a receptor and stimulates growth hormone release.
- 02CJC-1295 activates GHRH receptors on somatotroph cells.
- 03Combined action produces sustained physiological GH pulses.
- 04Preserves negative feedback via IGF-1 and somatostatin.
- 05Downstream IGF-1 supports muscle mass, recovery, and coat quality.
Molecular data
Species
Dog
Age-related GH decline documented. Preclinical dog data on ghrelin agonists exists. Combined use rests on the sermorelin extrapolation framework plus improved specificity of ipamorelin. Dog-only on the current nudaPETides prescription list. Feline data too thin for inclusion.
Prescribing indications
- EndocrineSupportedMuscle wasting in senior and post-illness dogs.
- RecoverySupportedRecovery from major orthopedic surgery.
- Oncology supportiveEmergingCachexia adjunct in cancer patients under specialist supervision.
Dosing and administration
Starting, maintenance, and loading doses are calculated in the platform for the patient’s weight band, at the vial strength our compounding partner dispenses, and drawn to U-100 syringe units for the client’s dosing card. Any override is logged with your initials.
See the worked dose exampleScreening and safety
Screen first
Diabetes, hyperadrenocorticism, neoplasia. Not for cats
Follow up
WSAVA body and muscle condition scores. Watch glucose. Measure at baseline and recheck at 4 to 6 weeks with the same measure.
References
Related
This monograph describes a compounded veterinary medication available by prescription only through a licensed veterinarian inside an active veterinarian-client-patient relationship. Not FDA-approved for animal or human use. Compounded on a patient-specific basis under FDA Guidance for Industry #256. For educational use by licensed veterinarians. Not intended for consumer self-prescribing.