Overview
GHK-Cu is one of the most studied regenerative peptides in the world. Four decades of research. Over four thousand gene expression changes documented. Direct canine wound healing evidence published in Veterinary Surgery.
The copper matters. It is the cofactor for lysyl oxidase and superoxide dismutase. That is why GHK-Cu outperforms GHK alone.
Mechanism of action
- 01Shifts the expression of genes tied to tissue remodeling, collagen synthesis, and wound repair.
- 02Activates collagen and glycosaminoglycan synthesis in fibroblasts.
- 03Accelerates re-epithelialization at wound margins.
- 04Delivers copper as cofactor for lysyl oxidase in collagen cross-linking.
- 05Provides antioxidant defense via superoxide dismutase support.
Molecular data
Species
Dog
Canapp 2003 in Veterinary Surgery documented accelerated ischemic wound healing in dogs with topical GHK-Cu. It is one of the few direct canine peptide citations, and it used a topical form. Through nudaPETides, GHK-Cu is prescribed as a subcutaneous injection.
Cat
Cats are excluded from the current GHK-Cu indication given copper metabolism differences and the risk of copper accumulation in susceptible breeds. Breed contraindications flagged.
Prescribing indications
- DermatologicPrimary useChronic non-healing wounds in dogs.
- RecoverySupportedPost-surgical dermal recovery.
- AestheticSupportedCoat quality and skin remodeling in senior dogs.
Dosing and administration
Starting, maintenance, and loading doses are calculated in the platform for the patient’s weight band, at the vial strength our compounding partner dispenses, and drawn to U-100 syringe units for the client’s dosing card. Any override is logged with your initials.
See the worked dose exampleScreening and safety
Screen first
Copper storage breeds: Bedlington, Labrador, Westie, Doberman
Follow up
Wound size or lesion photos at baseline and recheck. Measure at baseline and recheck at 4 to 6 weeks with the same measure.
Endogenous peptide. Excellent safety margin. Copper accumulation is the primary consideration in copper-storage susceptible breeds. Bedlington Terrier, Labrador Retriever, Dalmatian, and Doberman Pinscher require caution. Serum copper monitoring recommended for extended courses.
Common pairings
- BPC-157 + GHK-CuComplementarySee GLOW blend.
- GHK-Cu + TB-500ComplementarySee GLOW blend.
References
Related
This monograph describes a compounded veterinary medication available by prescription only through a licensed veterinarian inside an active veterinarian-client-patient relationship. Not FDA-approved for animal or human use. Compounded on a patient-specific basis under FDA Guidance for Industry #256. For educational use by licensed veterinarians. Not intended for consumer self-prescribing.