Welcome to nudaPETides. Coming soon.

The prescribing platform for veterinary peptide medicine. For licensed veterinarians.

Formulary
HepaticDog. CatTier A

Glutathione

The master antioxidant tripeptide. Hepatoprotection. Oxidative stress support.

Weight

307 Da

Half-life

Under 15 minutes IV

Chain

Tripeptide

Studies

15 referenced. Latest 2024.

Full monograph, dosing tables, and prescribing rationale are available to verified veterinarians with an active license and documented VCPR workflow. Request access to unlock the complete formulary library. Request access.

Overview

Glutathione is the master antioxidant of every cell in every mammal. It neutralizes reactive oxygen species. It conjugates and eliminates hepatotoxins. It regenerates other antioxidants. It powers phase two detoxification.

Direct canine data anchors this monograph. Not extrapolation. Real trials in real dogs.

Mechanism of action

  1. 01Directly neutralizes reactive oxygen species and free radicals.
  2. 02Cofactor for glutathione peroxidase in peroxide detoxification.
  3. 03Conjugates and eliminates hepatotoxins via phase two liver metabolism.
  4. 04Regenerates vitamin C and vitamin E in the cellular antioxidant network.
  5. 05Maintains cellular redox balance and mitochondrial function.

Molecular data

PropertyValue
Molecular weight307 Da
Chain length3 amino acids
TypeEndogenous tripeptide
RouteSubcutaneous or intravenous

Species applicability

Dog

Multiple published studies confirm reduced glutathione levels in canine liver disease, immune-mediated hemolytic anemia, and chronic inflammatory conditions. Supplementation improves biochemical markers and erythrocyte glutathione.

Cat

Cats are particularly susceptible to oxidative stress in acetaminophen toxicity. Glutathione replenishment is a documented supportive therapy. Feline hepatic lipidosis and cholangitis benefit from glutathione support.

Prescribing indications

HepaticMOST EFFECTIVE

Chronic hepatopathies in dogs and cats.

HematologicEFFECTIVE

Immune-mediated hemolytic anemia adjunct.

ToxicologyMOST EFFECTIVE

Acetaminophen toxicity in cats.

RenalEFFECTIVE

Chronic kidney disease supportive care.

Dosing framework

Full monograph, dosing tables, and prescribing rationale are available to verified veterinarians with an active license and documented VCPR workflow. Request access to unlock the complete formulary library.

Request access

Reconstitution and administration

Full monograph, dosing tables, and prescribing rationale are available to verified veterinarians with an active license and documented VCPR workflow. Request access to unlock the complete formulary library.

Request access

What to expect

Week 1 to 2Improved appetite in liver disease patients. Improved energy.
Week 2 to 4Bloodwork improvements in liver enzymes when applicable.
Week 4 to 8Sustained biochemical improvements. Better coat and body condition.

Research library

Bisanzio D et al. Antioxidant effect of fermentative S-acetyl-glutathione and silybin in dogs with liver disease. Veterinary Sciences.PMCBarry-Heffernan CA et al. Biomarkers of oxidative stress as an assessment of redox status of the liver in dogs. JVIM.PMCWoolcock AD et al. Reactive oxygen species, glutathione, and vitamin E in dogs with anemia. JVIM.WileyFatima CL et al. Oxidative stress in canine diseases. Antioxidants 2024.PMC

Related peptides

NAD+

Longevity

View

Thymosin Alpha-1

Immune

View

BPC-157

Recovery

View

Regulatory footing

This monograph describes a compounded veterinary medication available by prescription only through a licensed veterinarian inside an active veterinarian-client-patient relationship. Not FDA-approved for animal or human use. Compounded on a patient-specific basis under FDA Guidance for Industry #256. For educational use by licensed veterinarians. Not intended for consumer self-prescribing.

For licensed veterinarians only. Compounded under FDA GFI 256. Not FDA-approved.